Research
Taskforce 5 will develop three bioimaging plug & play pipelines tackling two viruses every year
Taskforce 5 Research Drivers
We will improve a therapeutics pipeline that takes in a pathogen’s genomic sequence and outputs structure-function information and small molecules that disrupt viral mechanisms. We specifically target replication, protease processing and RNA immune evasion.
To rapidly develop and enhance diagnostics, Taskforce 5 seeks to combine two of our discoveries: 1) we boosted protein antigen-based detection signal of SARSCoV-2 four-fold by using signaling antibodies that networked, and 2) PI (Hura), supported by DOE, co-developed Binary Biological Building Blocks (4Bs) that can create very large networked signaling sheets (collaboration with Baker lab at the University of Washington).
We aim to develop a unique DOE platform to rapidly optimize lipid nanoparticles (LNPs) for RNA vaccine design by attaining the right properties to optimize a consistent and predictable RNA-carrying LNPS for reproducibility and high-efficacy.
Taskforce 5 aims to integrate computational tools developed over decades and continue to develop new tools for integrated collection and analysis.